By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)
In 1988 we provided our consultant to Bone Marrow Transplan tation. The reception has been enthusiastic and we've re ceived a flood of serious reviews, feedback and requests to supply an replace in due time. even though numerous books on marrow transplantation have lately been released, their scope and objective have regularly been varied. therefore, we have now made up our minds to organize a moment variation of the advisor. Our objective was once to keep up a quick, concise textual content which by no means theless may include adjustments that experience happened over the last 4 or 5 years. now we have streamlined the outline of pretransplant issues, by means of condensing sections into one (Treatment making plans and Timing of Transplantation). This additionally facilitated the overview of arguable symptoms for marrow transplantation, for instance in sufferers with acute myelogenous leukemia in first chemotherapy-induced remission. we've got up to date the bankruptcy facing conditioning regimens and feature increased the part on donor choice, specifically in regard to the present point of tissue typing and the identity of unrelated volunteer donors. within the bankruptcy on assortment, processing, and infusion of marrow, we have now included fresh advancements, for instance, using closed platforms for marrow harvesting and processing and using strong part separation of stem cells.
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Extra resources for A Guide to Bone Marrow Transplantation
Two to six months or even more time may elapse before this work-up is complete, a transplant can be arranged, and a date for marrow harvest set. Autologous Marrow The current requirement for normal marrow status at the time of harvest largely limits autologous marrow transplantation 34 Pretransplant Considerations to use as a "rescue" procedure for certain cancer patients undergoing intensive cytotoxic therapy. However, once gene transfer procedures become practical, autologous marrow transplantation may be applicable to certain inherited immunohematologic disorders (Table 3).
50 Pre transplant Considerations acute leukemia patients in remission) and prompt confirmation is mandatory in these and all other cases. Ideally, tissues obtained from previous diagnostic studies should be reviewed by a pathologist who works closely with the Transplant Team. , a misclassification of the type or disease status of acute leukemia) may be important, as some Transplant Centers have different treatment regimens for these conditions. Disease Status For patients who have active malignant disease, it is important to know the sites and extent of disease.
N Engl J Med 321:1174-1178 Horowitz MM, Messerer D, Hoelzer D, Gale RP, Neiss A, Atkinson K, Barrett AJ, Buchner T, Freund M, Heil G, Hiddemann W, Kolb H-J, Treatment Planning and Timing of Transplantation 29 L6ffier H, Marmont AM, Maschmeyer G, Rimm AA, Rozman C, Sobocinski KA, Speck B, Thiel E, Weisdorf DJ, Zwaan FE, Bortin MM (1991) Chemotherapy compared with bone marrow transplantation for adults with acute lymphoblastic leukemia in first remission. Ann Intern Med 115:13-18 Klingemann H-G, Storb R, Fefer A, et al.