Download Advances in Tracer Methodology: Volume 3 A collection of by Sterling Chaykin (auth.), Seymour Rothchild (eds.) PDF

By Sterling Chaykin (auth.), Seymour Rothchild (eds.)

Radioactive tracers have had a profound influence on medical study up to now 20 years, really in bio­ chemistry and allied fields. The quick evolution of refined instrumentation and labeling suggestions in past times ten years has made attainable on a regimen foundation exquisitly delicate experiments which with different options will require her­ culean efforts at the a part of the investigator. The Symposia on Advances in Tracer method, which were held usually considering 1957, offer for learn employees in biochemistry, pharmacology, endocrinology, and drugs a spotlight at the a number of advancements within the tracer box which are often scattered in the course of the medical literature. quantity three is arecord of the court cases of the 9th and 10th Symposia, that have been backed by way of the recent England Nuclear company and the Packard tool corporation, Inc. fresh advances in tracer method, as mirrored via the papers during this quantity, were quite often fascinated by im­ proved analytical innovations, similar to liquid scintillation count number­ ing, autoradiography, and chromatography, and with novel ap­ plications of categorised compounds in biochemical and scientific problems.

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Straub, W•• Biochem. Z. 28:392 (1910). 16. , International Conference on Medicina1 Plant Research, Sofia (September 16-18, 1963). 17. Rabitzsch, G•• Naturwissenschaften 50:225 (1963). A SIMPLE METHOD OF PREPARING LABELED BENZENE K. Schmid, H. Fürer, and G. Dändliker eISA Research Laboratories Basel, Switzerland Among the organic compounds which may be employed as starting materials for radioactive syntheses, labeled benzene occupies an important position for several reasons. First, the tracer technique is one of the most widely used methods for studying the fate of drugs in the organism.

Unfortunately, it is still imposible to make more than a rough prediction about tritium incorporation. We have labeled aseries of purines and pyrimidines according to Wilzbach [2] which show only minor structural variations, and compared the obtained specific activities with relation to their chemical structure. The tritium exchange was performed in a glass apparatus [~ following a procedure which allowed the reversible desorption or sorption of the tritium from an uranium depot. After 14 days' exposure to tritium at 300 torr the compounds were purified by paper chromatography and measured in aqueous solution with a Packard 312 EX scintillation spectrometer.

LiAlH 4 reduction of the methyl ester gives rise to only propanol, without any allyl alcohol. 1 M LiAlH 4 and acryloyl chloride in ether at -40°C do give only allyl alcohol. Butthe formation of propanol becomes important with only a slight excess of LiAlH 4• Thus, in this reduction if allyl alcohol is desired it is necessary to know accurately the quantity of acryloyl chloride. ---.. i - H2 + CH2 =CH !! 2. H L. Pichat, M. Herbert, and F. Aubert 27 CHzNz CHzBr-CHBr-COOH 1 --_0 CHzBr-CHzBr-COOCHs [V] [VI] I AICl 3 Brz CHz=CH-COOH J LiAll\ + CHzBr-CHzBr-CHzOH [11 [VII] KMn04 (1) CH~-COOK (2) OH • CHzOH-CHOH-CHzOH [III] 1 CHzN z CH20H-CHzOH-COOH - - _ I CHzOH-CHzOH-COOCH3 [VIII] [IX] Fig.

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