Download Ageing: Lessons from C. elegans by Anders Olsen, Matthew S. Gill PDF

By Anders Olsen, Matthew S. Gill

This e-book brings jointly in a single quantity the present nation of growing older examine within the nematode Caenorhabditis elegans. The authors are best researchers within the box, putting this subject within the context of human growing old, describing how and why uncomplicated discoveries during this easy organism have impacted our customers for intervention within the growing old approach. The authors conceal a extensive diversity of themes just about organismal and reproductive growing old together with anatomical, physiological and biochemical alterations, in addition to genetic and environmental interventions that advertise sturdiness and ameliorate age-related disorder. getting old is the only most crucial issue selecting the onset of human illness in built international locations. With present around the globe demographic developments indicating that the variety of members over the age of sixty five will proceed to upward thrust, it truly is transparent that an figuring out of the methods that underpin getting older and age-related illness represents a key problem within the biomedical sciences. lately there were large advances in our realizing of the getting old approach and plenty of of those have stemmed from genetic research of C. elegans.

With no analogous publication during this topic zone this paintings could be of curiosity to a large viewers, starting from educational researchers to the overall public.

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This chapter will review the links between dauer formation and post-reproductive ageing. Keywords Ageing • Dauer • C. 1 Introduction In the natural environment, the dauer larval stage of C. elegans allows the animal to survive adverse conditions, while seeking out new food sources [1]. Dauer larvae are extremely long-lived, surviving for up to 70 days [2], compared with 10–15 days for the adult animal [3]. However, the adult lifespan of animals that have recovered from dauer is essentially the same, irrespective of the amount of time spent in dauer arrest [3].

C) Illustration showing progressive changes in the germline with age. In young adults, eggs are fertilized as they pass through the spermatheca. In middle-aged adults, egg-laying declines and fertilized and unfertilized embryos can collect in the uterus. A. Herndon et al. Fig. 14 Ageing adults develop germline masses of electron-dense acellular material. (a) TEM, transverse section, of a young adult hermaphrodite at low magnification. The distal portion of the gonad arm (dorsal) consists of thin gonadal sheath cells surrounding a syncytium of germ cells that are attached to a central cytoplasmic core (the rachis).

Elegans allows the animal to survive adverse conditions, while seeking out new food sources [1]. Dauer larvae are extremely long-lived, surviving for up to 70 days [2], compared with 10–15 days for the adult animal [3]. However, the adult lifespan of animals that have recovered from dauer is essentially the same, irrespective of the amount of time spent in dauer arrest [3]. These observations led to the conclusion that “dauer larvae seem to be able to reduce or suspend the rate of ageing” and that analysis of the dauer larva “may offer valuable insights into the controlling mechanisms of ageing” [3].

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